A novel serum metabolomics-based diagnostic approach for colorectal cancer.
作者: Shin NishiumiTakashi KobayashiAtsuki IkedaTomoo YoshieMegumi KibiYoshihiro IzumiTatsuya OkunoNobuhide HayashiSeiji KawanoTadaomi TakenawaTakeshi AzumaMasaru Yoshida
刊名: PLoS ONE, 2017, Vol.7 (7)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0040459
原始语种摘要: To improve the quality of life of colorectal cancer patients, it is important to establish new screening methods for early diagnosis of colorectal cancer.We performed serum metabolome analysis using gas-chromatography/mass-spectrometry (GC/MS). First, the accuracy of our GC/MS-based serum metabolomic analytical method was evaluated by calculating the RSD% values of serum levels of various metabolites. Second, the intra-day (morning, daytime, and night) and inter-day (among 3 days) variances of serum metabolite levels were examined. Then, serum metabolite levels were compared between colorectal cancer patients (N = 60; N = 12 for each stage from 0 to 4) and age- and sex-matched healthy volunteers (N = 60) as a training set. The metabolites whose levels displayed significant changes were...
全文获取路径: DOAJ  (合作)
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影响因子:3.73 (2012)

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关键词翻译
关键词翻译
  • colorectal 结肠直肠的
  • serum 血清
  • novel 长篇小说
  • established 确定
  • cancer 癌症
  • prediction 预报
  • screening 筛分
  • accuracy 准确度
  • confirmed 已确认的
  • metabolite 蚀变粗玻岩