Highly sensitive chemiluminescent aptasensor for detecting HBV infection based on rapid magnetic separation and double-functionalized gold nanoparticles
作者: Zhijiang XiQuan GongChao WangBing Zheng
刊名: Scientific Reports, 2018, Vol.8 (1), pp.1-7
来源数据库: Directory of Open Access Journals
DOI: 10.1038/s41598-018-27792-5
原始语种摘要: Abstract Hepatitis B virus (HBV) infection is a major global public health problem and one of the leading causes of chronic liver disease. HBsAg is the first serological marker to appear in the blood and is the most important marker of HBV infection. Detection of HBsAg in serum samples is commonly carried out using an immunoassay such as an enzyme-linked immunosorbent assay (ELISA), which is complex to perform, time-consuming, and unsatisfactory for testing sensitivity. Therefore, new methods for highly sensitive detection of HBV infection are urgently needed. Aptamers are specific recognition molecules with high affinity and specificity toward their targets. Biosensors that employ aptamers as biorecognition elements are known as aptasensors. In this study, we select an HBsAg-specific...
全文获取路径: DOAJ  (合作)
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影响因子:2.927 (2012)

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关键词翻译
关键词翻译
  • detection 探测
  • infection 感染
  • separation 分选
  • rapid 急流急滩
  • sensitive 灵敏的
  • detecting 检测
  • double 双重的
  • magnetic 磁的
  • highly 高度地
  • specific