Accuracy of indirect immunofluorescence on sodium chloride-split skin in the differential diagnosis of bullous pemphigoid and epidermolysis bullosa acquisita
作者: Baoqi YangChong WangShengli ChenXuechao ChenGuizhi ZhouHongqing TianMeiling YuDizhan ZhangZhongxiang ShiFuren Zhang
刊名: Indian Journal of Dermatology, Venereology and Leprology, 2011, Vol.77 (6), pp.677-682
来源数据库: Directory of Open Access Journals
DOI: 10.4103/0378-6323.86479
关键词: Bullous pemphigoidEpidermolysis bullosa acquisitaImmunoblottingIndirect immunofluorescence
原始语种摘要: Background: Previous reports have shown that indirect immunofluorescence (IIF) performed on sodium chloride-split skin (SSS) is helpful to differentiate epidermolysis bullosa acquisita (EBA) from bullous pemphigoid (BP). Antibodies of BP may bind to the epidermal side of SSS, while antibodies of EBA bind to the dermal side. Aims: To determine the accuracy of IIF-SSS in the differential diagnosis of EBA and BP utilizing immunoblotting (IB) analysis. Methods: Sera from 78 patients, diagnosed with BP by clinical features, histopathology, and direct immunofluorescence (DIF), were assayed using IIF-SSS and IB. Results: Of the 43 serum samples with an epidermal reaction to IIF-SSS assay, 42 were recognized with BP antigens (180 kDa or 230 kDa). Of the 11 serum samples with a dermal reaction...
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  • pemphigoid 类天疱疮
  • epidermolysis 表皮松解
  • bullous 大疱的
  • dermal 真皮的
  • indirect 间接的
  • differential 差动的
  • serum 血清
  • histopathology 组织病理学
  • sodium 
  • reaction 反酌