Angiogenesis impairment in diabetes: role of methylglyoxal-induced receptor for advanced glycation endproducts, autophagy and vascular endothelial growth factor receptor 2.
作者: Hongtao LiuShujie YuHua ZhangJian Xu
刊名: PLoS ONE, 2017, Vol.7 (10)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0046720
原始语种摘要: Diabetes impairs physiological angiogenesis by molecular mechanisms that are not fully understood. Methylglyoxal (MGO), a metabolite of glycolysis, is increased in patients with diabetes. This study defined the role of MGO in angiogenesis impairment and tested the mechanism in diabetic animals. Endothelial cells and mouse aortas were subjected to Western blot analysis of vascular endothelial growth factor receptor 2 (VEGFR2) protein levels and angiogenesis evaluation by endothelial cell tube formation/migration and aortic ring assays. Incubation with MGO reduced VEGFR2 protein, but not mRNA, levels in a time and dose dependent manner. Genetic knockdown of the receptor for advanced glycation endproducts (RAGE) attenuated the reduction of VEGFR2. Overexpression of Glyoxalase 1, the enzyme...
全文获取路径: DOAJ  (合作)
影响因子:3.73 (2012)

  • autophagy 自体消瘦
  • impairment 减损
  • angiogenesis 血管生成
  • methylglyoxal 丙酮醛
  • receptor 接受体
  • diabetes 糖尿病
  • induced 感应的
  • advanced 先进的
  • protein 蛋白质
  • diabetic 糖尿病患者