Functional studies on the IBD susceptibility gene IL23R implicate reduced receptor function in the protective genetic variant R381Q.
作者: Svetlana PidashevaSara TrifariAnne PhillipsJason A HackneyYan MaAshley SmithSue J SohnHergen SpitsRandall D LittleTimothy W BehrensLee HonigbergNico GhilardiHilary F Clark
刊名: PLoS ONE, 2017, Vol.6 (10)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0025038
原始语种摘要: Genome-wide association studies (GWAS) in several populations have demonstrated significant association of the IL23R gene with IBD (Crohn's disease (CD) and ulcerative colitis (UC)) and psoriasis, suggesting that perturbation of the IL-23 signaling pathway is relevant to the pathophysiology of these diseases. One particular variant, R381Q (rs11209026), confers strong protection against development of CD. We investigated the effects of this variant in primary T cells from healthy donors carrying IL23R(R381) and IL23R(Q381) haplotypes. Using a proprietary anti-IL23R antibody, ELISA, flow cytometry, phosphoflow and real-time RT-PCR methods, we examined IL23R expression and STAT3 phosphorylation and activation in response to IL-23. IL23R(Q381) was associated with reduced STAT3 phosphorylation...
全文获取路径: DOAJ  (合作)
影响因子:3.73 (2012)

  • function 函数
  • development 开发
  • reduced 减缩的
  • genetic 遗传的
  • variant 变体
  • particular 细致的
  • protection 保护
  • proprietary 控股
  • improved 改进
  • number 号码