Antimicrobial activity of meta-alkoxyphenylcarbamates containing substituted N-phenylpiperazine fragment
作者: Ivan MalíkMarián BukovskýFils AndriamaintyJana Gališinová
刊名: Brazilian Journal of Microbiology, 2012, Vol.43 (3), pp.959-965
来源数据库: Directory of Open Access Journals
DOI: 10.1590/S1517-83822012000300016
关键词: PhenylcarbamatesSubstituted N-phenylpiperazinesCandida albicans
原始语种摘要: In the present investigation, the basic esters of meta-alkoxyphenylcarbamic acid bearing variously substituted N-phenylpiperazine fragment were screened for their in vitro antimicrobial activity against Staphylococcus aureus, Escherichia coli and Candida albicans, respectively. The most effective against Escherichia coli was found the compound 6d (MIC=195,3 μg/mL) bearing simultaneously para-fluoro substituent at the 4‑phenylpiperazin-1-yl core and meta-methoxy side chain in the lipophilic part of the molecule. From whole analyzed set of the molecules the substance 8e with propoxy side chain forming meta-alkoxyphenylcarbamoyl fragment and lipophilic, sterically bulky meta-trifluoromethyl group attached at N-phenylpiperazine moiety was evaluated as the most active against Candida albicans...
全文获取路径: DOAJ  (合作)

  • fragment 碎屑
  • against 反对
  • albicans 白的
  • propoxy 丙氧基
  • lipophilic 亲油性
  • Candida 坎迪德
  • substituted 取代的
  • antimicrobial 杀菌剂
  • inactive 不活泼的
  • substituent 取代基