P-glycoprotein dysfunction contributes to hepatic steatosis and obesity in mice.
作者: Magali Foucaud-VignaultZeina SoayfaneCécile MénezJustine Bertrand-MichelPascal Guy Pierre MartinHervé GuillouXavier ColletAnne Lespine
刊名: PLoS ONE, 2017, Vol.6 (9)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0023614
原始语种摘要: Although the main role of P-glycoprotein (Pgp) is to extrude a broad range of xenochemicals and to protect the organism against xenotoxicity, it also transports a large range of endogenous lipids. Using mice lacking Pgp, we have investigated the possible involvement of Pgp in lipid homeostasis in vivo. In a long term study, we have followed the food intake, body status and lipid markers in plasma and liver of wild-type and mdr1ab(-/-) mice over 35 weeks. Pgp-deficient mice showed excess weight, hypertrophy of adipose mass, high insulin and glucose levels in plasma. Some of these metabolic disruptions appeared earlier in Pgp-deficient mice fed high-fat diet. Moreover, hepatosteatosis with increased expression of genes involved in liver detoxification and in de novo lipid synthesis occurred...
全文获取路径: DOAJ  (合作)
影响因子:3.73 (2012)

  • glycoprotein 糖蛋白
  • steatosis 脂肪变性
  • obesity 肥胖
  • lipid 脂质
  • hepatic 肝的
  • induced 感应的
  • dysfunction 功能障碍
  • resistant 耐久的
  • intake 收气
  • liver