In Vivo Molecular Imaging in Retinal Disease
作者: Fang XieWenting LuoZhongyu ZhangDawei Sun
作者单位: 1Department of Ophthalmology, First Affiliated Hospital of Harbin Medical University, Harbin 150001, China
2Department of Ophthalmology, Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China
刊名: Journal of Ophthalmology, 2012, Vol.2012
来源数据库: Directory of Open Access Journals
DOI: 10.1155/2012/429387
原始语种摘要: There is an urgent need for early diagnosis in medicine, whereupon effective treatments could prevent irreversible tissue damage. The special structure of the eye provides a unique opportunity for noninvasive light-based imaging of ocular fundus vasculature. To detect endothelial injury at the early and reversible stage of adhesion molecule upregulation, some novel imaging agents that target retinal endothelial molecules were generated. In vivo molecular imaging has a great potential to impact medicine by detecting diseases or screening disease in early stages, identifying extent of disease, selecting disease and patient-specific therapeutic treatment, applying a directed or targeted therapy, and measuring molecular-specific effects of treatment. Current preclinical findings and advances...
全文获取路径: DOAJ  (合作)
影响因子:1.368 (2012)

  • imaging 图像形成
  • findings 结论
  • preclinical 临证前期的
  • medicine 
  • irreversible 不可逆的
  • retinal 视黄醛
  • extent 范围
  • noninvasive 非扩散的
  • targeted 对准目标的
  • therapeutic 治疗的