Ki-67 marker useful for classification of malignant invasive ductal breast cancer
作者: Irmawati HassanTwidy TarcisiaAgnestina AgnestinaSantoso CornainI Made Nasar
作者单位: 1Department of Anatomical Pathology, Faculty of Medicine, Tarumanagara University
2Department of Histology, Faculty of Medicine, Tarumanagara University
3Department of Public Health, Faculty of Medicine, Tarumanagara University
4Department of Anatomical Pathology, Faculty of Medicine, University of Indonesia.
5Stem Cell and Cancer Institute
刊名: Universa Medicina, 2015, Vol.32 (3), pp.179-186
来源数据库: Directory of Open Access Journals
DOI: 10.1805/UnivMed.2013.v32.179-186
关键词: Ki-67 proliferative indexGradingDuctal invasive breast cancer
原始语种摘要: BACKGROUNDBreast cancer is an important health problem in the world. Uncontrolled cell proliferation represents a malignant characteristic of neoplasia such as breast cancer, and can be examined immunohistochemically by measuring the Ki-67 proliferative marker. The objective of this study was to determine the role of Ki-67 for classification of the degree of malignancy in women with invasive ductal breast cancer.METHODSA cross-sectional study was conducted on 20 women with invasive ductal breast cancer. The samples were immuno-histochemically tested for Ki-67 using anti-Ki-67 primary antibody. The Ki-67 proliferative index was determined by enumerating the proportion of Ki-67 positive nuclei among the total number of cells in ten areas observed at 400x magnification, using a 20% cut-off...
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关键词翻译
关键词翻译
  • ductal 管的
  • breast 胸部
  • invasive 侵入的
  • cancer 癌症
  • malignancy 恶性
  • marker 标试器
  • malignant 恶性的
  • grade 品位
  • significantly 较大地
  • classification 分类