Mucoadhesive drug delivery systems
作者: Flávia Chiva CarvalhoMarcos Luciano BruschiRaul Cesar EvangelistaMaria Palmira Daflon Gremião
刊名: Brazilian Journal of Pharmaceutical Sciences, 2010, Vol.46 (1), pp.1-17
来源数据库: Directory of Open Access Journals
DOI: 10.1590/S1984-82502010000100002
关键词: MucoadesãoBioadesãoSistemas mucoadesivosFármacosMucoadhesionBioadhesionMucoadhesive systemsDrugs
原始语种摘要: Drug actions can be improved by developing new drug delivery systems, such as the mucoadhesive system. These systems remain in close contact with the absorption tissue, the mucous membrane, releasing the drug at the action site leading to a bioavailability increase and both local and systemic effects. Mucoadhesion is currently explained by six theories: electronic, adsorption, wettability, diffusion, fracture and mechanical. Several in vitro and in vivo methodologies are proposed for studying its mechanisms. However, mucoadhesion is not yet well understood. The aim of this study was to review the mechanisms and theories involved in mucoadhesion, as well as to describe the most-used methodologies and polymers in mucoadhesive drug delivery systems.O efeito de fármacos pode ser...
全文获取路径: DOAJ  (合作)

  • systems 系统科学与软件
  • action 行为
  • mechanical 机械的
  • proposed 建议的
  • delivery 移交
  • improved 改进
  • well 
  • electronic 电子的
  • local 局部的
  • remain