Physicochemical Characteristics and Anti-Inflammatory Activities of Antrodan, a Novel Glycoprotein Isolated from Antrodia cinnamomea Mycelia
作者: Chun-Hung ChiuChiung-Chi PengYaw-Bee KerChin-Chu ChenArwen LeeWan-Lin ChangCharng-Cherng ChyauRobert Y. Peng
作者单位: 1esearch Institute of Biotechnology, Hungkuang University, 34 Chung-Chie Road, Shalu District, Taichung 433, Taiwan
2Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei 11031, Taiwan
3Department of Applied Food Technology, Hungkuang University, 34 Chung-Chie Road, Shalu District, Taichung 433, Taiwan
4Grape King Biotechnology Inc., Zhongli City, Taoyuan County 320, Taiwan
5Research Institute of Biotechnology, Hungkuang University, 34 Chung-Ch
刊名: Molecules, 2013, Vol.19 (1), pp.22-40
来源数据库: Directory of Open Access Journals
DOI: 10.3390/molecules19010022
关键词: Antrodia cinnamomeaMyceliaGlycoproteinAntrodanStructureAnti-inflammatory activity
原始语种摘要: Antrodia cinnamomea (AC) is a unique fungus found inhabiting the rotten wood of Cinnamomum kanehirai. A submerged liquid culture of AC has been developed and its bioproducts have been used to meet the market demand for natural fruiting bodies. AC exhibits anti-inflammatory, antitumor, antioxidant, and immunomodulatory effects. Previously, we isolated polysaccharide AC-2 from AC mycelia by means of alkali extraction with subsequent acid precipitation and found it had a pronounced anti-inflammatory effect. In this study, a novel polysaccharide named “antrodan” was obtained by further purification of AC-2 using Sepharose CL-6B column chromatography. Antrodan exhibited a molecular weight of 442 kD and contained a particularly high content of uronic acid (152.6 ± 0.8 mg/g). The protein content...
全文获取路径: DOAJ  (合作)
影响因子:2.428 (2012)

  • intramolecular 分子内的
  • inflammatory 激怒的
  • amide 酰胺
  • content 品位
  • linked 连接的
  • sugars 
  • bonds 公债
  • apparently 显然地
  • amino 氨基
  • liquid 液体