Peptidylarginine Deiminase Inhibitors Reduce Bacterial Membrane Vesicle Release and Sensitize Bacteria to Antibiotic Treatment
作者: Uchini S. KosgodagePaul MateweleGiulia MastroianniIgor KraevDominik BrothertonBrigitte AwamariaAnthony P. NicholasSigrun LangeJameel M. Inal
刊名: Frontiers in Cellular and Infection Microbiology, 2019, Vol.9
来源数据库: Directory of Open Access Journals
DOI: 10.3389/fcimb.2019.00227
关键词: Outer-membrane vesicles (OMVs)Peptidylarginine deiminase (PAD)Deimination/citrullinationAntibiotic sensitivityE. coli VCS257S. aureus subsp. aureus Rosenbach
原始语种摘要: Outer membrane and membrane vesicles (OMV/MV) are released from bacteria and participate in cell communication, biofilm formation and host-pathogen interactions. Peptidylarginine deiminases (PADs) are phylogenetically conserved enzymes that catalyze post-translational deimination/citrullination of proteins, causing structural and functional changes in target proteins. PADs also play major roles in the regulation of eukaryotic extracellular vesicle release. Here we show phylogenetically conserved pathways of PAD-mediated OMV/MV release in bacteria and describe deiminated/citrullinated proteins in E. coli and their derived OMV/MVs. Furthermore, we show that PAD inhibitors can be used to effectively reduce OMV/MV release, both in Gram-negative and Gram-positive bacteria. Importantly, this...
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  • 细菌 平移的
  • 胞外的 平移的
  • antibiotic 抗生素
  • PAD Pilot Horizontal Display
  • release 释放
  • Release 免除释放机构
  • membrane 
  • proteins 蛋白质
  • participate 参加
  • translational 平移的
  • bacteria 平移的
  • extracellular 平移的