Apoptosis of the fibrocytes type 1 in the spiral ligament and blood labyrinth barrier disturbance cause hearing impairment in murine cerebral malaria
作者: Schmutzhard JoachimKositz Christian HGlueckert RudolfSchmutzhard ErichSchrott-Fischer AnneliesLackner Peter
刊名: Malaria Journal, 2012, Vol.11 (1)
来源数据库: Directory of Open Access Journals
DOI: 10.1186/1475-2875-11-30
关键词: Murine cerebral malariaHearing impairmentApoptosisSpiral ligament fibrocytesBlood labyrinth barrier
原始语种摘要: Abstract Background Experimental murine malaria has been shown to result in significant hearing impairment. Microscopic evaluation of the temporal bones of these animals has revealed regular morphology of the cochlea duct. Furthermore, the known vascular pathologic changes being associated with malaria could not be found. Immunohistochemistry for ICAM1 showed a strong marking in the stria vascularis , indicating a disturbance of the endocochlear potential. The aim of this study was to evaluate the role of apoptosis and the disturbance of the blood labyrinth barrier in the murine malaria associated hearing impairment. Methods The temporal bones of seven mice with cerebral malaria-four with hearing impairment, three without hearing impairment-were evaluated with immunohistochemistry for...
全文获取路径: DOAJ  (合作)
影响因子:3.4 (2012)

  • labyrinth 迷宫
  • hearing 听觉
  • impairment 减损
  • malaria 疟疾
  • ligament 韧带
  • murine 鼠灰色
  • barrier 堡坝
  • cochlea 耳蜗
  • spiral 螺旋形的
  • cerebral 大脑的