Biosynthesis and Molecular Genetics of Polyketides in Marine Dinoflagellates
作者: Ralf KellmannAnke StükenRussell J. S. OrrHelene M. SvendsenKjetill S. Jakobsen
刊名: Marine Drugs, 2010, Vol.8 (4), pp.1011-1048
来源数据库: Directory of Open Access Journals
DOI: 10.3390/md8041011
关键词: PolyketidesPolyether toxinsAlkaloidsMolecular geneticsGenomicsBiosynthesis
原始语种摘要: Marine dinoflagellates are the single most important group of algae that produce toxins, which have a global impact on human activities. The toxins are chemically diverse, and include macrolides, cyclic polyethers, spirolides and purine alkaloids. Whereas there is a multitude of studies describing the pharmacology of these toxins, there is limited or no knowledge regarding the biochemistry and molecular genetics involved in their biosynthesis. Recently, however, exciting advances have been made. Expressed sequence tag sequencing studies have revealed important insights into the transcriptomes of dinoflagellates, whereas other studies have implicated polyketide synthase genes in the biosynthesis of cyclic polyether toxins, and the molecular genetic basis for the biosynthesis of paralytic...
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影响因子:3.978 (2012)

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关键词翻译
关键词翻译
  • dinoflagellate 甲藻
  • paralytic 麻痹的
  • Marine 海军(部)海军陆战队almanac 航海历
  • genetics 遗传学
  • biosynthesis 生物合成
  • shellfish 
  • sequencing 排序
  • polyketide 多聚乙酰
  • macrolides 大环内酯
  • there 那里