Roles of Peroxisome Proliferator-Activated Receptor α in Bitter Melon Seed Oil-Corrected Lipid Disorders and Conversion of α-Eleostearic Acid into Rumenic Acid in C57BL/6J Mice
作者: Ya-Yuan ChangHui-Min SuSzu-Han ChenWen-Tsong HsiehJong-Ho ChyuanPei-Min Chao
作者单位: 1Department of Nutrition, China Medical University, Taichung 404, Taiwan
2Graduate Institute of Physiology, National Taiwan University, Taipei 100, Taiwan
3School of Medicine, China Medical University, Taichung 404, Taiwan
4Hualien District Agricultural Research and Extension Station, Hualien 973, Taiwan
刊名: Nutrients, 2016, Vol.8 (12)
来源数据库: Directory of Open Access Journals
DOI: 10.3390/nu8120805
关键词: PPARαBitter melon seed oilHepatic steatosisObesityΑ-eleostearic acid
原始语种摘要: We previously reported that bitter melon seed oil (BMSO) was an effective anti-steatosis and antiobesity agent. Since the major fatty acid α-eleostearic acid (α-ESA) in BMSO is a peroxisome proliferator-activated receptor α (PPARα) activator, the objective was to investigate the role of PPARα in BMSO-modulated lipid disorders and α-ESA metabolism. C57BL/6J wild (WD) and PPARα knockout (KO) mice were fed a high-fat diet containing BMSO (15% soybean oil + 15% BMSO, HB) or not (30% soybean oil, HS) for 5 weeks. The HB diet significantly reduced hepatic triglyceride concentrations and increased acyl-CoA oxidase activity in WD, but not in KO mice. However, regardless of genotype, body fat percentage was lowered along with upregulated protein levels of uncoupling protein 1 (UCP1) and tyrosine...
全文获取路径: DOAJ  (合作)
影响因子:2.072 (2012)

  • Bitter 比特尔牌汽车
  • steatosis 脂肪变性
  • adipose 脂肪的
  • adiposity 肥胖
  • protein 蛋白质
  • uncoupling 解开连结
  • triglyceride 甘油三酯
  • melon 甜瓜
  • hydroxylase 羟基化酶
  • ESA European Space Agency