Microglia Polarization with M1/M2 Phenotype Changes in rd1 Mouse Model of Retinal Degeneration
作者: Tian ZhouZijing HuangXiaowei SunXiaowei ZhuLingli ZhouMei LiBing ChengXialin LiuChang He
刊名: Frontiers in Neuroanatomy, 2017, Vol.11
来源数据库: Directory of Open Access Journals
DOI: 10.3389/fnana.2017.00077
关键词: MicrogliaActivationPolarizationNeuroinflammationRetinal degenerationRd1
原始语种摘要: Microglia activation is recognized as the hallmark of neuroinflammation. However, the activation profile and phenotype changes of microglia during the process of retinal degeneration are poorly understood. This study aimed to elucidate the time-spatial pattern of microglia distribution and characterize the polarized phenotype of activated microglia during retinal neuroinflammation and degeneration in rd1 (Pde6βrd1/rd1) mice, the classic model of inherited retinal degeneration. Retinae of rd1 mice at different postnatal days (P7, P14, P21, P28, P56, and P180) were prepared for further analysis. We found most CD11b+ or IBA1+ microglia expressed Ki-67 and CD68 in rd1 mice and these cells migrated toward the layer of degenerative photoreceptors at the rapid rods degeneration phase from P14 to...
全文获取路径: DOAJ  (合作)
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影响因子:4.058 (2012)

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关键词翻译
关键词翻译
  • microglia 小神经胶质细胞
  • retinal 视黄醛
  • degeneration 退化
  • degenerative 退化的
  • ameboid 变形虫样的
  • increased 增加
  • polarized 极化的
  • postnatal 出生后的
  • understood 明白
  • panorama 全景图