The teratogenicity and the action mechanism of gallic acid relating with brain and cervical muscles.
作者: Chiu Lan HsiehChien-Hong LinKuan Chou ChenChiung-Chi PengRobert Y Peng
刊名: PLoS ONE, 2017, Vol.10 (6)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0119516
原始语种摘要: Gallic acid (3,4,5-trihydroxybenzoic acid) (GA) and other flavanoids are extensively used in nutraceuticals because of their antioxidant and antiinflammatory properties. While examining whether GA is effective in alleviating valproic-acid-induced teratogenesis in a chicken embryo model (CEM), we observed embryo hemorrhage and liposis in the musculi longissimus cervicis. We conducted this study to determine whether GA is inherently teratogenic and the extent to which the risk can be transferred to fetuses. A CEM was used to administer GA at 2, 6, 10, and 14 μM. GA at 2 μM did not exhibit cytotoxicity. At 6, 10, and 14 μM, GA caused severe decreases in body and liver weights, causing -5.6%, -21.3%, and -27.5% body weights and 4.0, 3.8, and 3.2-g, liver weights, respectively, in day-1...
全文获取路径: DOAJ  (合作)
影响因子:3.73 (2012)

  • teratogenicity 致畸态性
  • cervical 颈的
  • gallic 制图布
  • musculi 肌肉
  • muscles 筋肉
  • mechanism 机构
  • longissimus 最长肌
  • brain 
  • potentially 可能地
  • teratogenesis 畸形形成