Loss of secreted frizzled-related protein 4 correlates with an aggressive phenotype and predicts poor outcome in ovarian cancer patients.
作者: Francis JacobKristjan UkegjiniSheri NixdorfCaroline E FordJake OlivierRosmarie CaduffJames P ScurryRea GuertlerDaniela HornungRenato MuellerDaniel A FinkNeville F HackerViola A Heinzelmann-Schwarz
刊名: PLoS ONE, 2017, Vol.7 (2)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0031885
原始语种摘要: BACKGROUND: Activation of the Wnt signaling pathway is implicated in aberrant cellular proliferation in various cancers. In 40% of endometrioid ovarian cancers, constitutive activation of the pathway is due to oncogenic mutations in β-catenin or other inactivating mutations in key negative regulators. Secreted frizzled-related protein 4 (SFRP4) has been proposed to have inhibitory activity through binding and sequestering Wnt ligands. METHODOLOGY/PRINCIPAL FINDINGS: We performed RT-qPCR and Western-blotting in primary cultures and ovarian cell lines for SFRP4 and its key downstream regulators activated β-catenin, β-catenin and GSK3β. SFRP4 was then examined by immunohistochemistry in a cohort of 721 patients and due to its proposed secretory function, in plasma, presenting the first ELISA...
全文获取路径: DOAJ  (合作)
影响因子:3.73 (2012)

  • ovarian 卵巢的
  • protein 蛋白质
  • aggressive 侵蚀的
  • borderline 边线
  • endometrioid 子宫内膜样的
  • cancer 癌症
  • phenotype 表型
  • epigenetic 后成的
  • pathway 轨道
  • expressed 榨出的