Impact of microRNA expression in human atrial tissue in patients with atrial fibrillation undergoing cardiac surgery.
作者: Hiroyuki NishiTaichi SakaguchiShigeru MiyagawaYasushi YoshikawaSatsuki FukushimaShunsuke SaitoTakayoshi UenoToru KurataniYoshiki Sawa
刊名: PLoS ONE, 2017, Vol.8 (9)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0073397
原始语种摘要: BACKGROUND: Although microRNA (miRNA) regulates initiation and/or progression of atrial fibrillation (AF) in canine AF models, the underlying mechanism in humans remains unclear. We speculated that certain miRNAs in atrial tissue are related to AF, and evaluated the relationship of miRNA expression in human atrial tissue in cardiac surgery patients. METHODS: Right atrial tissues from 29 patients undergoing cardiovascular surgery were divided into 3 groups [A: chronic AF or unsuccessful maze, n=6; B: successful maze, n=10; C: sinus rhythm (SR) n=13]. miRNA expression was determined using high density microarrays and with Reverse transcriptase-polymerase chain reaction (RT-PCR). Fibrosis was examined using Masson trichrome staining. RESULTS: miRNA microarray analysis showed elevated...
全文获取路径: DOAJ  (合作)
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影响因子:3.73 (2012)

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关键词翻译
关键词翻译
  • atrial 围鳃的
  • fibrillation 原纤维化
  • expression 表示
  • cardiac 贲门
  • tissue 组织
  • human 人的
  • unsuccessful 不成功
  • rhythm 韵律
  • fibrosis 纤维化
  • usefulness 有效