Protective Effects of Taraxasterol against Ethanol-Induced Liver Injury by Regulating CYP2E1/Nrf2/HO-1 and NF-κB Signaling Pathways in Mice
作者: Lu XuYifan YuRui SangJinxia LiBingjie GeXuemei Zhang
作者单位: 1epartment of Animal Medicine, Agricultural College of Yanbian University, Gongyuan Street, Yanji, Jilin 133002, China
2Department of Animal Medicine, Agricultural College of Yanbian University, Gongyuan Street, Yanji, Jilin 133002, China
3Department of Animal Medicine, Ag
刊名: Oxidative Medicine and Cellular Longevity, 2018, Vol.2018
来源数据库: Directory of Open Access Journals
DOI: 10.1155/2018/8284107
原始语种摘要: Taraxasterol, a pentacyclic-triterpene compound, is one of the main active components isolated from the traditional Chinese medicinal herb Taraxacum. The objective of this study is to evaluate the protective effects of taraxasterol and its possible underlying mechanisms against ethanol-induced liver injury in mice. ICR mice were fed with Lieber-DeCarli diet containing 5% ethanol for 10 d and then challenged with a single dose of 20% ethanol (5 g/kg BW) by intragastric administration. The mice were intragastrically treated daily with taraxasterol (2.5, 5, and 10 mg/kg). Tiopronin was used as a positive control. The liver index was calculated, and the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglyceride (TG), tumor necrosis factor-α (TNF-α), and...
全文获取路径: DOAJ  (合作)
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影响因子:3.393 (2012)

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关键词翻译
关键词翻译
  • ethanol 乙醇
  • liver 
  • taraxasterol 蒲公英甾醇
  • against 反对
  • induced 感应的
  • hepatic 肝的
  • significantly 较大地
  • aspartate 天冬氨酸盐
  • findings 结论
  • factor 因素