Cardioprotective properties of omentin-1 in type 2 diabetes: evidence from clinical and in vitro studies.
作者: Sabrina GreulichWeena J Y ChenBujar MaxheraLuuk J RijzewijkRutger W van der MeerJacqueline T JonkerHeidi MuellerDaniella Herzfeld de WizaRalf-Ruediger FloerkeKonstantinos SmirisHildo J LambAlbert de RoosJeroen J BaxJohannes A RomijnJan W A SmitPayam AkhyariArtur LichtenbergJuergen EckelMichaela DiamantD Margriet Ouwens
刊名: PLoS ONE, 2017, Vol.8 (3)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0059697
原始语种摘要: CONTEXT: Adipokines are linked to the development of cardiovascular dysfunction in type 2 diabetes (DM2). In DM2-patients, circulating levels of omentin-1, an adipokine preferentially expressed in epicardial adipose tissue, are decreased. This study investigated whether omentin-1 has a cardioprotective function. METHODS: Omentin-1 levels in plasma and cardiac fat depots were determined in DM2-patients versus controls. Moreover, the relation between omentin-1 levels and cardiac function was examined in men with uncomplicated DM2. Finally, we determined whether omentin-1 could reverse the induction of cardiomyocyte dysfunction by conditioned media derived from epicardial adipose tissue from patients with DM2. RESULTS: Omentin-1 was highly expressed and secreted by epicardial adipose tissue,...
全文获取路径: DOAJ  (合作)
影响因子:3.73 (2012)

  • diabetes 糖尿病
  • adipose 脂肪的
  • dysfunction 功能障碍
  • epicardial 心外膜的
  • evidence 
  • uncomplicated 简单
  • insulin 胰岛素
  • conditioned 经过调节的
  • deceleration 减速
  • diastolic 舒张的