Characterization of apolipoprotein A-I peptide phospholipid interaction and its effect on HDL nanodisc assembly
作者: Patel HDing BErnst KShen LYuan WTang JDrake LRKang JLi YChen ZSchwendeman A
刊名: International Journal of Nanomedicine, 2019, Vol.Volume 14 , pp.3069-3086
来源数据库: Directory of Open Access Journals
关键词: ApoA-1 mimetic peptideHDLHigh density lipoproteinLUVLarge unilamellar vesicleSFGSum frequency generationDLSDynamic light scatteringTEMTransmission electron microscopy
原始语种摘要: Hiren Patel,1 Bei Ding,2 Kelsey Ernst,3 Lei Shen,2 Wenmin Yuan,3 Jie Tang,3 Lindsey R Drake,1 Jukyung Kang,3 Yaoxin Li,2 Zhan Chen,2 Anna Schwendeman1,3,41Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA; 2Department of Chemistry, University of Michigan, Ann Arbor, MI, USA; 3Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA; 4Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USABackground: Synthetic HDLs (sHDLs), small nanodiscs of apolipoprotein mimetic peptides surrounding lipid bilayers, were developed clinically for atheroma regression in cardiovascular patients. Formation of HDL involves interaction of apolipoprotein A-I (ApoA-I) with phospholipid bilayers and assembly...
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影响因子:3.463 (2012)

  • phospholipid 磷脂
  • apolipoprotein 脱脂蛋白
  • mimetic 模仿的
  • assembly 组装
  • peptide 
  • phosphocholine 胆碱磷酸
  • density 密度
  • generation 世代
  • DLS Data Link Subsystem
  • vesicle 气泡