Inhibition of G protein-activated inwardly rectifying K+ channels by different classes of antidepressants.
作者: Toru KobayashiKazuo WashiyamaKazutaka Ikeda
刊名: PLoS ONE, 2017, Vol.6 (12)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0028208
原始语种摘要: Various antidepressants are commonly used for the treatment of depression and several other neuropsychiatric disorders. In addition to their primary effects on serotonergic or noradrenergic neurotransmitter systems, antidepressants have been shown to interact with several receptors and ion channels. However, the molecular mechanisms that underlie the effects of antidepressants have not yet been sufficiently clarified. G protein-activated inwardly rectifying K(+) (GIRK, Kir3) channels play an important role in regulating neuronal excitability and heart rate, and GIRK channel modulation has been suggested to have therapeutic potential for several neuropsychiatric disorders and cardiac arrhythmias. In the present study, we investigated the effects of various classes of antidepressants on...
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影响因子:3.73 (2012)

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关键词翻译
关键词翻译
  • protein 蛋白质
  • inwardly 在内部
  • mianserin 米安舍林
  • serotonergic 含血清素的
  • therapeutic 治疗的
  • amoxapine 阿莫沙平
  • independent 独立的
  • excitability 兴奋性
  • rectifying 精馏
  • depression 低地