TMF inhibits miR-29a/Wnt/Β-catenin signaling through upregulating Foxo3a activity in osteoarthritis chondrocytes
作者: Huang XChen ZShi WZhang RLi LLiu HWu L
刊名: Drug Design, Development and Therapy, 2019, Vol.Volume 13 , pp.2009-2019
来源数据库: Directory of Open Access Journals
关键词: OsteoarthritisChondrocytes apoptosisMiR-29aWnt/β-cateninFoxo3aTMF
原始语种摘要: Xianhua Huang*, Zhixi Chen*, Weimei Shi, Rui Zhang, Linfu Li, Hai Liu, Longhuo WuCollege of Pharmacy, Gannan Medical University, Ganzhou, People’s Republic of China*These authors contributed equally to this work Background: miR-29a, a downstream factor of Wnt/Β-catenin signaling, promotes the activity of the Wnt/Β-catenin signaling in a positive feedback loop. Our previous work showed that 5,7,3ʹ,4ʹ-tetramethoxyflavone (TMF), a major constituent from Murraya exotica L., exhibited chondroprotective activity by inhibiting the activity of Wnt/Β-catenin signaling.Purpose: To investigate whether TMF showed the inhibitory effects on miR-29a/Β-catenin signaling by up regulation of Foxo3a expression.Methods: Rat knee OA models were duplicated by using Hulth’s method. TMF (5 Μg/mL and 20 Μg/mL)...
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影响因子:3.486 (2012)

  • signaling 发信号
  • osteoarthritis 骨关节炎
  • activity 活度
  • TMF Time Marker Frequency
  • regulated 规定
  • expression 表示
  • inhibiting 抑制
  • luciferase 荧光素酶
  • transfection 转染
  • reporter 报告生成程序