The diagnostic performance of a novel ELISA for human CTP (Cochlin-tomoprotein) to detect perilymph leakage.
作者: Tetsuo IkezonoTomohiro MatsumuraHan MatsudaSatomi ShikazeShiho SaitohSusumu ShindoSetsuo HasegawaSeung Ha OhYoshiaki HagiwaraYasuo OgawaHiroshi OgawaHiroaki SatoTetsuya TonoRyuichiro ArakiYukihide MaedaShin-Ichi UsamiYasuhiro Kase
刊名: PLoS ONE, 2018, Vol.13 (1)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0191498
原始语种摘要: Perilymphatic fistula is defined as an abnormal communication between the perilymph-filled space and the middle ear, or cranial spaces. The manifestations include a broad spectrum of neuro-otological symptoms such as hearing loss, vertigo/dizziness, disequilibrium, aural fullness, tinnitus, and cognitive dysfunction. By sealing the fistula, perilymphatic fistula is a surgically correctable disease. Also, appropriate recognition and treatment of perilymphatic fistula can improve a patient's condition and hence the quality of life. However, the difficulty in making a definitive diagnosis due to the lack of an appropriate biomarker to detect perilymph leakage has caused a long-standing debate regarding its management. We have reported a clinical test for the diagnosis of perilymphatic...
全文获取路径: DOAJ  (合作)
影响因子:3.73 (2012)

  • perilymph 外淋巴
  • ELISA 酶联免疫吸收分析
  • diagnostic 诊断的
  • tinnitus 耳鸣
  • CTP Coordinated Test Program
  • aural 听觉的
  • vertigo 眩晕
  • hearing 听觉
  • human 人的
  • fistula 喙管