Human Umbilical Cord-Derived Mesenchymal Stem Cells Improve Learning and Memory Function in Hypoxic-Ischemic Brain-Damaged Rats via an IL-8-Mediated Secretion Mechanism Rather than Differentiation Pattern Induction
作者: Xiaoqin ZhouJialu GuYan GuMulan HeYang BiJie ChenTingyu Li
刊名: Cellular Physiology and Biochemistry, 2015, Vol.35 (6), pp.2383-2401
来源数据库: Directory of Open Access Journals
DOI: 10.1159/000374040
关键词: Human umbilical cord-derived mesenchymal stem cellsHypoxic-ischemic brain damageIL-8Learning-memory functionDifferentiation
原始语种摘要: Background: MSCs are a promising therapeutic resource. Paracrine effects and the induction of differentiation patterns are thought to represent the two primary mechanisms underlying the therapeutic effects of mesenchymal stem cell (MSC) transplantation in vivo. However, it is unclear which mechanism is involved in the therapeutic effects of human umbilical cord-derived MSC (hUC-MSC) transplantation. Methods and Results: Based on flow cytometry analysis, hUC-MSCs exhibited the morphological characteristics and surface markers of MSCs. Following directed neural induction, these cells displayed a neuron-like morphology and expressed high levels of neural markers. All types of hUC-MSCs, including differentiated and redifferentiated cells, promoted learning and memory function recovery in...
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关键词翻译
关键词翻译
  • therapeutic 治疗的
  • umbilical 供应脐带
  • mesenchymal 间叶细胞的
  • brain 
  • angiogenesis 血管生成
  • cells 麻风细胞
  • markers 时标
  • induction 诱发
  • hypoxic 含氧量低的
  • Induction 感应