Assessing Mucoadhesion in Polymer Gels: The Effect of Method Type and Instrument Variables
作者: Jéssica Bassi da SilvaSabrina Barbosa de Souza FerreiraAdriano Valim ReisMichael Thomas CookMarcos Luciano Bruschi
作者单位: 1aboratory of Research and Development of Drug Delivery Systems, Postgraduate Program in Pharmaceutical Sciences, Department of Pharmacy, State University of Maringa, Maringa, Parana CEP 87020-900, Brazil
2Laboratory of Research and Development of Drug Delivery Systems, Postgraduate Program in Pharmaceutical Sciences, Department of Pharmacy, State University of Maringa, Maringa, Parana CEP 87020-900, Brazil
3Laboratory of Research and Development of Drug Delivery Systems, Postgraduate Program in Pharmaceutic
刊名: Polymers, 2018, Vol.10 (3)
来源数据库: Directory of Open Access Journals
DOI: 10.3390/polym10030254
关键词: Pluronic f127Thermoresponsive polymersThermogelling polymersDetachment forceRheologyTexture profile analysis
原始语种摘要: The process of mucoadhesion has been widely studied using a wide variety of methods, which are influenced by instrumental variables and experiment design, making the comparison between the results of different studies difficult. The aim of this work was to standardize the conditions of the detachment test and the rheological methods of mucoadhesion assessment for semisolids, and introduce a texture profile analysis (TPA) method. A factorial design was developed to suggest standard conditions for performing the detachment force method. To evaluate the method, binary polymeric systems were prepared containing poloxamer 407 and Carbopol 971P®, Carbopol 974P®, or Noveon® Polycarbophil. The mucoadhesion of systems was evaluated, and the reproducibility of these measurements investigated. This...
全文获取路径: DOAJ  (合作)
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关键词翻译
关键词翻译
  • standardize 使标准化
  • design 设计
  • force 
  • evaluate 求...的值
  • detachment 脱顶构造
  • method 方法
  • process 过程
  • adhesion 粘附
  • demonstrated 探明的储量
  • more 更多