Expression of MMP-1/PAR-1 and patterns of invasion in oral squamous cell carcinoma as potential prognostic markers
作者: Fan HXChen YNi BXWang SSun MChen DZheng JH
刊名: OncoTargets and Therapy, 2015, Vol.2015 (default), pp.1619-1626
来源数据库: Directory of Open Access Journals
原始语种摘要: Hai-Xia Fan,1 Yan Chen,1 Bo-Xiong Ni,1 Shan Wang,1 Miao Sun,2 Dong Chen,2 Jin-Hua Zheng11Department of Anatomy, Basic Medical Science College, 2Department of Oral and Maxillofacial Surgery, Stomatological Hospital, Harbin Medical University, Harbin, People’s Republic of ChinaBackground: Matrix metalloproteinase (MMP)-1 degrades type I collagen of the extracellular matrix and also activates protease activated receptor (PAR)-1 to induce angiogenesis. The aims of this study were to evaluate microvessel density (MVD) and the expression of PAR-1 and MMP-1 in oral squamous cell carcinoma (SCC) specimens with different patterns of invasion (POI) and to evaluate their association with clinical outcomes.Methods: Seventy-four surgically obtained oral SCC samples were classified by POI according to...
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影响因子:2.073 (2012)

  • squamous 具鳞的
  • carcinoma 癌症
  • PAR Page Address Register
  • potential 
  • invasion 侵入
  • prognostic 预测的
  • markers 时标
  • survival 生存
  • prognosis 预报
  • expression 表示