Gene Expression Indicates Altered Immune Modulation and Signaling Pathway Activation in Ovarian Cancer Patients Resistant to Topotecan
作者: Otília MenyhártJános Tibor FeketeBalázs Győrffy
刊名: International Journal of Molecular Sciences, 2019, Vol.20 (11)
来源数据库: Directory of Open Access Journals
DOI: 10.3390/ijms20112750
关键词: Ovarian carcinomaResistanceBiomarkerGene expressionGene arraysSurvivalTumor microenvironment
原始语种摘要: Epithelial ovarian cancer (EOC) is one of the deadliest gynecological malignancies. Topotecan remains an essential tool in second-line therapy; even so, most patients develop resistance within a short period of time. We aimed to identify biomarkers of topotecan resistance by using gene expression signatures derived from patient specimens at surgery and available subsequent responses to therapy. Gene expression was collected for 1436 patients and 10,103 genes. Based on disease progression, patients were categorized as responders/nonresponders depending on their progression free survival (PFS) state at 9, 12, 15 and 18 months after surgery. For each gene, the median expression was compared between responders and nonresponders for two treatment regimens (chemotherapy including/excluding...
全文获取路径: DOAJ  (合作)
影响因子:2.464 (2012)

  • chemotherapy 化学疗法
  • gynecological 妇科学的
  • ovarian 卵巢的
  • carcinoma 癌症
  • expression 表示
  • survival 生存
  • consistently 一贯地
  • progression 级数
  • remains 残渣
  • essential 本质的