Individually Tailored Screening of Susceptibility to Sarcopenia Using p53 Codon 72 Polymorphism, Phenotypes, and Conventional Risk Factors
作者: Laura Di RenzoSanto GratteriFrancesca SarloAndrea CabibboCarmen ColicaAntonino De Lorenzo
作者单位: 1epartment of Biomedicine and Prevention, Division of Clinical Nutrition and Nutrigenomics, University of Rome “Tor Vergata”, Via Montpellier 1, 00133 Rome, Italy
2Department of Surgery and Medical Science, University “Magna Graecia”, 88100 Germaneto, Italy
3Department of Agriculture, University of Naples “Federico II”, 80055 Portici, Italy
4Department of Biology, University of Rome “Tor Vergata”, 00133 Rome, Italy
5CNR, ISN UOS of Pharmacology, Department of Pharmacology, University “Magna Graecia”, 88100 R
刊名: Disease Markers, 2014, Vol.2014
来源数据库: Directory of Open Access Journals
DOI: 10.1155/2014/743634
原始语种摘要: Background and Aim. p53 activity plays a role in muscle homeostasis and skeletal muscle differentiation; all pathways that lead to sarcopenia are related to p53 activities. We investigate the allelic frequency of the TP53 codon 72 in exon 4 polymorphism in the Italian female population and the association with appendicular skeletal muscle mass index in normal weight (NW), normal weight obese (NWO), and preobese-obese (Preob-Ob) subjects. Methods. We evaluated anthropometry, body composition, and p53 polymorphism in 140 women distinguished in NW, NWO, and Preob-Ob. Results. Arg*/Arg* genotype increases sarcopenia risk up to 20% (Arg*/Arg* genotype OR = 1.20; 95% CI = 0.48–2.9; proallele* carriers OR = 0.83; 95% CI = 0.83–2.06). The risk of being sarcopenic for Arg*/Arg* genotype in NWO and...
全文获取路径: DOAJ  (合作)
影响因子:2.14 (2012)

  • polymorphism 多晶形
  • investigate 
  • genotype 属型
  • allelic 等位的
  • population 母体
  • muscle 肌肉
  • anthropometry 人体测量术
  • weight 
  • obese 肥胖的
  • codon 码字