Selective Inhibition of Mammalian DNA Polymerase by Vitamin D2 and D3
作者: Yoshiyuki MizushinaXianai XuChikako MurakamiToshio OkanoMasaharu TakemuraHiromi YoshidaKengo Sakaguchi
刊名: Journal of Pharmacological Sciences, 2019, Vol.92 (3), pp.283-290
来源数据库: Directory of Open Access Journals
原始语种摘要: As described previously (H. Togashi et al. Biochem Pharmacol. 1998;56:583–590), the irradiated products of provitamin D2 (ergosterol) inhibit the activities of eukaryotic DNA polymerases. In this report, therefore, we investigated whether vitamin D and its related compounds inhibited the activities of DNA polymerases. As expected, vitamin D2 and vitamin D3 were found to be selective inhibitors of mammalian DNA polymerase a (pol a) with IC50 values of 123 and 96 μM, respectively. On the other hand, provitamin D2, provitamin D3, and the active form of vitamin D3 such as 1a,25-dihydroxyvitamin D3 could not influence any of the DNA polymerase activities. Interestingly, vitamin D3-3β-sulfate was a much stronger pol a inhibitor with an IC50 value of 7.1 μM. Vitamin D2, vitamin D3, and vitamin...
全文获取路径: DOAJ  (合作)
影响因子:2.15 (2012)

  • provitamin 前维生素
  • polymerase 聚合酶
  • previously 以前
  • whether 是否
  • inhibitor 抑制剂
  • DNA Deoxyribonucleic Acid
  • expected 预期
  • respectively 分别
  • sulfate 硫酸盐
  • values 价值观