Knockdown of cyclooxygenase-2 leads to growth inhibition and cell cycle arrest in hepatocellular carcinoma cells
作者: Lv XChen ZLi SXie H
刊名: OncoTargets and Therapy, 2019, Vol.Volume 12 , pp.4341-4349
来源数据库: Directory of Open Access Journals
关键词: COX-2RNA interferenceHepatocellular carcinoma
原始语种摘要: Xiuhe Lv,* Zhen Chen,* Shaohua Li, Huahong XieState Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Air Force Military Medical University/Fourth Military Medical University, Xi’an 710032, Shaanxi Province, People’s Republic of China*These authors contributed equally to this work Background & aims: Cyclooxygenase-2 (COX-2) is proved to play important roles in the development and progression of various human tumors, including hepatocellular carcinoma (HCC). However, the antitumor effect of RNA interference (RNAi) technology targeting COX-2 in HCC has not yet been verified.Methods: We silenced COX-2 expression using a lentivirus-mediated RNAi and further investigated the effects of COX-2 knockdown on cell...
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影响因子:2.073 (2012)

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关键词翻译
关键词翻译
  • hepatocellular 肝细胞性的
  • knockdown 击倒
  • expression 表示
  • carcinoma 癌症
  • leads 引线
  • interference 干涉
  • antitumor 抗癌的
  • arrest 制动器
  • cells 麻风细胞
  • detected 找到