Bioactive Phenylalanine Derivatives and Cytochalasins from the Soft Coral-Derived Fungus, Aspergillus elegans
作者: Xue-Ping SunGuang-Ying ChenDong-Lin ZhaoKai-Ling WangMin ChenLu-Yong WuChang-Lun ShaoCai-Juan ZhengChang-Yun Wang
刊名: Marine Drugs, 2013, Vol.11 (6), pp.2054-2068
来源数据库: Directory of Open Access Journals
DOI: 10.3390/md11062054
关键词: Soft coral-derived fungusAspergillus elegansPhenylalanine derivativeCytochalasinAntifouling
原始语种摘要: One new phenylalanine derivative 4′-OMe-asperphenamate (1), along with one known phenylalanine derivative (2) and two new cytochalasins, aspochalasin A1 (3) and cytochalasin Z24 (4), as well as eight known cytochalasin analogues (5–12) were isolated from the fermentation broth of Aspergillus elegans ZJ-2008010, a fungus obtained from a soft coral Sarcophyton sp. collected from the South China Sea. Their structures and the relative configurations were elucidated using comprehensive spectroscopic methods. The absolute configuration of 1 was determined by chemical synthesis and Marfey’s method. All isolated metabolites (1–12) were evaluated for their antifouling and antibacterial activities. Cytochalasins 5, 6, 8 and 9 showed strong antifouling activity against the larval settlement of the...
全文获取路径: DOAJ  (合作)
影响因子:3.978 (2012)

  • derivative 衍生物
  • phenylalanine 苯丙氨酸
  • antifouling 防污
  • larval 幼虫的
  • fungus 真菌
  • barnacle 贝壳
  • coral 珊瑚
  • activity 活度
  • antibacterial 抗细菌的
  • especially 特别地