Ginsenoside Rb1 prevents H2O2-induced HUVEC senescence by stimulating sirtuin-1 pathway.
作者: Zhiming SongYong LiuBaoshun HaoShujie YuHui ZhangDinghui LiuBin ZhouLin WuMin WangZhaojun XiongChaodong WuJieming ZhuXiaoxian Qian
刊名: PLoS ONE, 2017, Vol.9 (11)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0112699
原始语种摘要: We have previously reported that Ginsenoside Rb1 may effectively prevent HUVECs from senescence, however, the detailed mechanism has not demonstrated up to now. Recent studies have shown that sirtuin-1 (Sirt1) plays an important role in the development of endothelial senescence. The purpose of this study was to explore whether Sirt1 is involved in the action of Ginsenoside Rb1 regarding protection against H2O2-induced HUVEC Senescence.Senescence induced by hydrogen peroxide (H2O2) in human umbilical vein endothelial cells (HUVECs) was examined by analyzing plasminogen activator inhibitor-1 (PAI-1) expression, cell morphology, and senescence-associated beta-galactosidase (SA-β-gal) activity. The results revealed that 42% of control-treated HUVECs were SA-β-gal positive after treatment by...
全文获取路径: DOAJ  (合作)
影响因子:3.73 (2012)

  • senescence 衰老
  • stimulating 促进
  • induced 感应的
  • pathway 轨道
  • against 反对
  • expression 表示
  • acetylation 乙酰化
  • umbilical 供应脐带
  • protect 庇护
  • endothelial 内皮的