Association between the polymorphisms in intercellular adhesion molecule-1 and the risk of coronary atherosclerosis: a case-controlled study.
作者: Mao YangZhenkun FuQingjiang ZhangYu XinYanjun ChenYe Tian
刊名: PLoS ONE, 2017, Vol.9 (10)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0109658
原始语种摘要: Intercellular adhesion molecule-1 (ICAM-1), an important immune adhesion molecule, is related to the atherosclerosis. We explored the association between the polymorphisms of the ICAM-1 gene and coronary atherosclerotic stenosis to determine whether any risk factors correlate with genetic polymorphisms in Chinese patients with coronary atherosclerosis. Using the SNaPshot assay, we examined six SNPs of rs5491, rs281428, rs281432, rs5496, rs5498 and rs281437 in 604 patients diagnosed with coronary atherosclerotic stenosis by angiography and in 468 controls. We found that AG genotype of rs5498 had higher frequency in the coronary atherosclerotic stenosis patients (41.56% to 34.19%, P = 0.017, OR = 1.368,95%CI 1.057-1.770) and that the haplotype Ars5491Crs281428Grs281432 had higher frequency...
全文获取路径: DOAJ  (合作)
影响因子:3.73 (2012)

  • coronary 冠状的
  • adhesion 粘附
  • molecule 分子
  • stenosis 压缩
  • apolipoprotein 脱脂蛋白
  • Association 美国公共卫生协会
  • associated 相关的
  • controlled 受控
  • angiography 血管照相术
  • correlate 联系数