Serum PlGF and EGF are independent prognostic markers in non-metastatic colorectal cancer
作者: Sebastian SchölchAndreas BognerUlrich BorkMohammad RahbariBalázs GyőrffyMartin SchneiderChristoph ReissfelderJürgen WeitzNuh N. Rahbari
刊名: Scientific Reports, 2019, Vol.9 (1), pp.1-12
来源数据库: Directory of Open Access Journals
DOI: 10.1038/s41598-019-47429-5
原始语种摘要: Abstract The aim of this study was to determine the prognostic value of circulating angiogenic cytokines in non-metastatic colorectal cancer (CRC) patients. Preoperative serum samples of a training (TC) (n = 219) and a validation cohort (VC) (n = 168) were analyzed via ELISA to determine PlGF, EGF, VEGF, Ang1, PDGF-A, PDGF-B, IL-8 and bFGF levels. In addition, survival was correlated with PlGF and EGF expression measured by microarray and RNAseq in two publicly available, independent cohorts (n = 550 and n = 463, respectively). Prognostic values for overall (OS) and disease-free survival (DFS) were determined using uni- and multivariate Cox proportional hazard analyses. Elevated PlGF is predictive for impaired OS (TC: HR 1.056; p = 0.046; VC: HR 1.093; p = 0.001) and DFS (TC: HR 1.052; p...
全文获取路径: DOAJ  (合作)
影响因子:2.927 (2012)

  • prognostic 预测的
  • EGF 表皮生长因子
  • metastatic 新陈代谢的
  • colorectal 结肠直肠的
  • markers 时标
  • independent 独立的
  • survival 生存
  • cancer 癌症
  • correlated 相关
  • prognosis 预报