Association of four genetic polymorphisms of AGER and its circulating forms with coronary artery disease: a meta-analysis.
作者: Feng PengDan HuNan JiaXiaobo LiYuqiong LiShaoli ChuDingliang ZhuWeifeng ShenJinxiu LinWenquan Niu
刊名: PLoS ONE, 2017, Vol.8 (7)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0070834
原始语种摘要: BACKGROUND: Considerable efforts have been devoted to evaluating the association of the receptor for advanced glycation end-products (gene AGER and protein: RAGE) genetic variants to coronary artery disease (CAD); the results, however, are often irreproducible. To generate more information, we sought to explore four common polymorphisms of AGER and its circulating forms associated with the risk of CAD via a meta-analysis. METHODOLOGY/PRINCIPAL FINDINGS: Articles were identified by searching PubMed, EMBASE, Wanfang and CNKI databases before March 2013. Qualified articles had case-control designs and investigated AGER four polymorphisms (T-429C, T-374A, Gly82Ser, G1704A) or circulating soluble RAGE (sRAGE) or endogenous secretory RAGE (esRAGE) levels associated with CAD. Twenty-seven...
全文获取路径: DOAJ  (合作)
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影响因子:3.73 (2012)

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关键词翻译
关键词翻译
  • 探明的储量 糖尿病
  • genetic 遗传的
  • CAD Character Assemble/Disassemble
  • circulating 循环
  • coronary 冠状的
  • estimates 估值
  • analysis 分析
  • lower 降下
  • diabetes 糖尿病
  • demonstrated 糖尿病
  • forms 格式