Antagonistic cross-regulation between Sox9 and Sox10 controls an anti-tumorigenic program in melanoma.
作者: Olga ShakhovaPhil ChengPravin J MishraDaniel ZinggSimon M SchaeferJulien DebbacheJessica HäuselClaudia MatterTheresa GuoSean DavisPaul MeltzerDaniela Mihic-ProbstHolger MochMichael WegnerGlenn MerlinoMitchell P LevesqueReinhard DummerRaffaella SantoroPaolo CinelliLukas Sommer
刊名: PLoS Genetics, 2015, Vol.11 (1)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pgen.1004877
原始语种摘要: Melanoma is the most fatal skin cancer, but the etiology of this devastating disease is still poorly understood. Recently, the transcription factor Sox10 has been shown to promote both melanoma initiation and progression. Reducing SOX10 expression levels in human melanoma cells and in a genetic melanoma mouse model, efficiently abolishes tumorigenesis by inducing cell cycle exit and apoptosis. Here, we show that this anti-tumorigenic effect functionally involves SOX9, a factor related to SOX10 and upregulated in melanoma cells upon loss of SOX10. Unlike SOX10, SOX9 is not required for normal melanocyte stem cell function, the formation of hyperplastic lesions, and melanoma initiation. To the contrary, SOX9 overexpression results in cell cycle arrest, apoptosis, and a gene expression...
全文获取路径: DOAJ  (合作)
影响因子:8.517 (2012)

  • melanoma 黑瘤
  • tumorigenic 致瘤的
  • program 程序
  • controls 控制机构
  • hyperplastic 境生的
  • functionally 就其功能
  • tumorigenesis 瘤形成
  • initiation 创始
  • etiology 病原学
  • expression 表示