An association between initiation of selective serotonin reuptake inhibitors and suicide - a nationwide register-based case-crossover study.
作者: Charlotte BjörkenstamJette MöllerGunilla RingbäckPeter SalmiJohan HallqvistRickard Ljung
刊名: PLoS ONE, 2017, Vol.8 (9)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0073973
原始语种摘要: BACKGROUND: Treatment with selective serotonin reuptake inhibitors (SSRI) is one of the most common treatments for depression. It is however not clear whether or not there is an increased short-term suicide risk during initiation with SSRI. METHODS: A register-based nationwide case-crossover study including 5,866 suicides, 1,698 women and 4,168 men, from the Death Register 2007-2010 in Sweden. SSRI initiation was defined as a dispensed prescription of SSRI within 28 days prior to the date of suicide with no previous dispensed prescription of SSRI within 4 months prior that prescription. The control period took place one year earlier. Odds ratio (OR) was estimated using conditional logistic regression. RESULT: During the 28 day period prior to suicide 48 women and 138 men were exposed to...
全文获取路径: DOAJ  (合作)
影响因子:3.73 (2012)

  • reuptake 再摄取
  • serotonin 血清素
  • suicide 自杀
  • initiation 创始
  • nationwide 全国
  • selective 选择性的
  • crossover 交叉
  • previous 先前的
  • exposed 被辐照的
  • association 联合