Comparison of the Apoptotic Effects of Supercritical Fluid Extracts of Antrodia cinnamomea Mycelia on Hepatocellular Carcinoma Cells
作者: Hsiu-Man LienChun-Hung ChiuChia-Chang ChenWan-Lin ChangCharng-Cherng ChyauRobert Y. Peng
作者单位: 1epartment of Chemistry, Tunghai University, No.1727, Sec. 4, Taiwan Boulevard, Xitun District, Taichung 40704, Taiwan
2Research Institute of Biotechnology, Hungkuang University, No. 1018, Sec. 6, Taiwan Boulevard, Shalu District, Taichung 43302, Taiwan
3Yusheng Biotechnology Center, No. 26, Keyuan Rd., Xitun District, Taichung 40763, Taiwan
4Research Institute of Biotechnolo
刊名: Molecules, 2014, Vol.19 (7), pp.9033-9050
来源数据库: Directory of Open Access Journals
DOI: 10.3390/molecules19079033
关键词: Antrodia cinnamomeaSolid-state cultureSupercritical fluid extractHepG2 cellApoptotic activity
原始语种摘要: Antrodia cinnamomea (AC) has been widely used as a folk medicine in the prevention and treatment of liver diseases, such as hepatitis, hepatic fibrosis, and hepatocellular carcinoma. Previous studies have indicated that triterpenoids and benzenoids show selective cytotoxicity against human hepatoma cell lines. The aim of the study was to compare the triterpenoid content of extract and the extract-induced cytotoxicity in HepG2 cells from mycelia extracts of solid state cultured AC obtained by supercritical fluid extraction (SFE) and the conventional solvent extraction method. SFE with CO2 mixed with a constant amount of ethanol co-solvent (10% of CO2 volume) applied at different temperatures and pressures (40, 60 and 80 °C and, 20.7, 27.6 and 34.5 Mpa) was also compared in the study....
全文获取路径: DOAJ  (合作)
影响因子:2.428 (2012)

  • extraction 提取
  • hepatocellular 肝细胞性的
  • iodide 碘化物
  • ethanol 乙醇
  • hepatoma 肝癌
  • state 状态
  • extracts 摘记
  • dimethoxy 二甲氧基
  • compared 肿瘤和正常组织细胞周期的比较
  • cytotoxicity 细胞毒性