Highly Enantioselective Addition of Phenylethynylzinc to Aldehydes Catalyzed by Chiral Cyclopropane-Based Amino Alcohols
作者: Bing ZhengZhiyuan LiFeipeng LiuYanhua WuJunjian ShenQinghua BianShicong HouMing Wang
作者单位: 1epartment of Applied Chemistry, China Agricultural University, 2 West Yuanmingyuan Road, Beijing 100193, China
2Yanlin Agriculture Bureau, 20 Huadu Avenue, Yanlin 461200, Henan, China
3Department of Applied Chemistry, China Agricultural University, 2 West Yuanmingyuan Road, Beijing 100193, China
4Department of Applied Chemistry, China Agricultural University, 2 West Yuanmingyuan Road, Beijing 100
刊名: Molecules, 2013, Vol.18 (12), pp.15422-15433
来源数据库: Directory of Open Access Journals
DOI: 10.3390/molecules181215422
关键词: AlkynylationAldehydesCyclopropane-basedAmino alcoholsAsymmetric catalysis
原始语种摘要: The enantioselective addition of phenylethynylzinc to aldehydes catalyzed by a series of cyclopropane-based amino alcohol ligands 7 was investigated. The reactions afforded chiral propargylic alcohols in high yields (up to 96%) and with excellent enantioselectivities (up to 98% ee) under mild conditions. Furthermore, studies on the structural relationship show that the matching of the chiral center configuration is crucial to obtain the high enantioselectivity.
全文获取路径: DOAJ  (合作)
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影响因子:2.428 (2012)

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关键词翻译
关键词翻译
  • alcohols 醇类
  • chiral 手性的
  • aldehydes 
  • cyclopropane 环丙烷
  • catalysis 催化
  • catalyzed 催化的
  • amino 氨基
  • matching 匹配
  • relationship 关系
  • configuration 配置