Systematic assessment of prescribed medications and short-term risk of myocardial infarction – a pharmacopeia-wide association study from Norway and Sweden
作者: Abhijit SenIoannis VardaxisBo Henry LindqvistBen Michael BrumptonLinn Beate StrandInger Johanne BakkenLars Johan VattenPål Richard RomundstadRickard LjungKenneth Jay MukamalImre Janszky
刊名: Scientific Reports, 2019, Vol.9 (1), pp.1-10
来源数据库: Directory of Open Access Journals
DOI: 10.1038/s41598-019-44641-1
原始语种摘要: Abstract Wholesale, unbiased assessment of Scandinavian electronic health-care databases offer a unique opportunity to reveal potentially important undiscovered drug side effects. We examined the short-term risk of acute myocardial infarction (AMI) associated with drugs prescribed in Norway or Sweden. We identified 24,584 and 97,068 AMI patients via the patient- and the cause-of-death registers and linked to prescription databases in Norway (2004–2014) and Sweden (2005–2014), respectively. A case-crossover design was used to compare the drugs dispensed 1–7 days before the date of AMI diagnosis with 15–21 days’ time -window for all the drug individually while controlling the receipt of other drugs. A BOLASSO approach was used to select drugs that acutely either increase or decrease the...
全文获取路径: DOAJ  (合作)
影响因子:2.927 (2012)

  • infarction 梗塞
  • myocardial 心肌的
  • AMI Access Method Interface
  • pharmacopeia 药典
  • assessment 评价
  • adrenergics 肾上腺素能物质
  • prescribed 法定
  • associated 相关的
  • angiotensin 血管紧张肽
  • Norway 挪威