A novel form of memory for auditory fear conditioning at a low-intensity unconditioned stimulus.
作者: Ayumi KishiokaFumiaki FukushimaTamae ItoHirotaka KataokaHisashi MoriToshio IkedaShigeyoshi ItoharaKenji SakimuraMasayoshi Mishina
刊名: PLoS ONE, 2017, Vol.4 (1)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0004157
原始语种摘要: Fear is one of the most potent emotional experiences and is an adaptive component of response to potentially threatening stimuli. On the other hand, too much or inappropriate fear accounts for many common psychiatric problems. Cumulative evidence suggests that the amygdala plays a central role in the acquisition, storage and expression of fear memory. Here, we developed an inducible striatal neuron ablation system in transgenic mice. The ablation of striatal neurons in the adult brain hardly affected the auditory fear learning under the standard condition in agreement with previous studies. When conditioned with a low-intensity unconditioned stimulus, however, the formation of long-term fear memory but not short-tem memory was impaired in striatal neuron-ablated mice. Consistently, the...
全文获取路径: DOAJ  (合作)
影响因子:3.73 (2012)

  • unconditioned 无条件
  • auditory 听觉的
  • intensity 强度
  • stimulus 刺激
  • memory 记忆
  • striatal 纹状体的
  • conditioning 
  • ablation 剥蚀
  • novel 长篇小说
  • inappropriate 不适当的