The number of x chromosomes causes sex differences in adiposity in mice.
作者: Xuqi ChenRebecca McCluskyJenny ChenSimon W BeavenPeter TontonozArthur P ArnoldKaren Reue
刊名: PLoS Genetics, 2017, Vol.8 (5)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pgen.1002709
原始语种摘要: Sexual dimorphism in body weight, fat distribution, and metabolic disease has been attributed largely to differential effects of male and female gonadal hormones. Here, we report that the number of X chromosomes within cells also contributes to these sex differences. We employed a unique mouse model, known as the "four core genotypes," to distinguish between effects of gonadal sex (testes or ovaries) and sex chromosomes (XX or XY). With this model, we produced gonadal male and female mice carrying XX or XY sex chromosome complements. Mice were gonadectomized to remove the acute effects of gonadal hormones and to uncover effects of sex chromosome complement on obesity. Mice with XX sex chromosomes (relative to XY), regardless of their type of gonad, had up to 2-fold increased adiposity and...
全文获取路径: DOAJ  (合作)
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影响因子:8.517 (2012)

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关键词翻译
关键词翻译
  • distinguish 辨别
  • adiposity 肥胖
  • gonadal 生殖腺的
  • carrying 垫纱
  • complements 互补商品
  • attributed 属性
  • female 女性的
  • obesity 肥胖
  • effects 海员自身物品
  • dosage 放射剂量