The therapeutic protection of a living and dead Lactobacillus strain against aluminum-induced brain and liver injuries in C57BL/6 mice.
作者: Fengwei TianLeilei YuQixiao ZhaiYue XiaoYing ShiJinchi JiangXiaoming LiuJianxin ZhaoHao ZhangWei Chen
刊名: PLoS ONE, 2017, Vol.12 (4)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0175398
原始语种摘要: Our previous study found that Lactobacillus plantarum CCFM639 had the ability to alleviate acute aluminum (Al) toxicity when the strain was introduced simultaneously with Al exposure. This research was designed to elucidate the therapeutic effects of living and dead L. plantarum CCFM639 against chronic Al toxicity and to gain insight into the protection modes of this strain. Animals were assigned into control, Al only, Al + living CCFM639, and Al + dead CCFM639 groups. The Al exposure model was established by drinking water for the first 4 weeks. The strain was given after Al exposure by oral gavage at 109 colony-forming units once per day for 12 weeks. The results show that the Al binding ability of dead CCFM639 was similar to that of living CCFM639 in vitro. The ingestion of living or...
全文获取路径: DOAJ  (合作)
影响因子:3.73 (2012)

  • protection 保护
  • against 反对
  • aluminum 
  • strain 应变
  • therapeutic 治疗的
  • living 生存的
  • ability 能力
  • induced 感应的
  • similar 类似的例子
  • supplement 附录