Combined olaparib and oxaliplatin inhibits tumor proliferation and induces G2/M arrest and Γ-H2AX foci formation in colorectal cancer
作者: Xu KChen ZCui YQin CHe YSong X
刊名: OncoTargets and Therapy, 2015, Vol.2015 (default), pp.3047-3054
来源数据库: Directory of Open Access Journals
原始语种摘要: Kaiwu Xu,1* Zhihui Chen,2* Yi Cui,1 Changjiang Qin,2 Yulong He,2 Xinming Song2 1Endoscopy Center, 2Gastrointestinal Surgery Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, People’s Republic of China *These authors contributed equally to this work Background: Poly (ADP-ribose) polymerase 1 (PARP1) has an important role in homologous recombination repair. The purpose of this study was to investigate the effect of PARP1 inhibitor on oxaliplatin treatment for colorectal cancer (CRC). Methods: A cell counting kit-8 assay was used to determine the sensitivity of CRC cells to olaparib and/or oxaliplatin. The gene and protein expressions of PARP1 and the gamma histone variant H2AX (ΓH2AX) were measured by real-time quantitative polymerase chain...
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影响因子:2.073 (2012)

  • formation 建造
  • investigate 
  • homologous 同结构型的
  • colorectal 结肠直肠的
  • recombination 再化合
  • examine 
  • treatment 处理
  • expression 表示
  • assay 试金
  • equally 同等地