APEX nuclease (multifunctional DNA repair enzyme) 1 gene Asp148Glu polymorphism and cancer risk: a meta-analysis involving 58 articles and 48903 participants.
作者: Dan HuXiandong LinHejun ZhangXiongwei ZhengWenquan Niu
刊名: PLoS ONE, 2017, Vol.8 (12)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0083527
原始语种摘要: BACKGROUND: Polymorphisms in the APEX nuclease (multifunctional DNA repair enzyme) 1 gene (APEX1) may be involved in the carcinogenesis by affecting DNA repair. We aimed to summarize available data on the association of the APEX1 Asp148Glu (rs1130409) polymorphism with risk of multiple types of cancer via a meta-analysis. METHODS AND RESULTS: In total, 58 qualified articles including 22,398 cancer patients and 26,505 controls were analyzed, and the data were extracted independently by two investigators. Analyses of the full data set indicated a marginally significant association of the APEX1 Asp148Glu polymorphism with cancer risk under allelic (odds ratio (OR)=1.05; 95% confidence interval (95% CI): 0.99-1.11; P=0.071), dominant (OR=1.09; 95% CI: 1.01-1.17; P=0.028), and heterozygous...
全文获取路径: DOAJ  (合作)
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影响因子:3.73 (2012)

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关键词翻译
关键词翻译
  • nuclease 核酸酶
  • polymorphism 多晶形
  • nonsignificant 无意义的
  • analysis 分析
  • heterozygous 杂合的
  • articles 用品
  • DNA Deoxyribonucleic Acid
  • estimates 估值
  • cancer 癌症
  • available 可供应的