Hematopoietically-expressed homeobox gene three widely-evaluated polymorphisms and risk for diabetes: a meta-analysis.
作者: Xiaobo LiYuqiong LiBei SongShujie GuoShaoli ChuNan JiaWenquan Niu
刊名: PLoS ONE, 2017, Vol.7 (11)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0049917
原始语种摘要: BACKGROUND: The hematopoietically-expressed homeobox (HHEX) gene is identified as a promising candidate for type 2 diabetes by genome-wide association studies, triggering plenty of subsequent replications; however, the results are conflicting. We therefore conducted a meta-analysis of three widely-evaluated polymorphisms in HHEX gene and diabetes risk. METHODOLOGY/PRINCIPAL FINDINGS: A random-effects model was adopted irrespective of heterogeneity. Data and study quality were assessed in duplicate. There were 49 studies (cases/controls: 57931/74658) for rs1111875, 18 studies (18227/30366) for rs5015480 and 26 studies (25725/30579) for rs7923837, respectively. Overall analyses indicated that rs1111875-C allele (odds ratio [OR] = 1.16; 95% confidence interval [CI]: 1.13-1.2; P<0.0005),...
全文获取路径: DOAJ  (合作)
影响因子:3.73 (2012)

  • homeobox 同源[异型]框
  • expressed 榨出的
  • widely 广泛地
  • diabetes 糖尿病
  • three 
  • analysis 分析
  • allele 等位基因
  • random 随机的
  • association 联合
  • estimates 估值