Decreased Intracellular pH Induced by Cariporide Differentially Contributes to Human Umbilical Cord-Derived Mesenchymal Stem Cells Differentiation
作者: Wei GaoHairui ZhangGuoqiang ChangZhenqing XieHanyu WangLi MaZhongchao HanQinghua LiTianxiang Pang
刊名: Cellular Physiology and Biochemistry, 2014, Vol.33 (1), pp.185-194
来源数据库: Directory of Open Access Journals
DOI: 10.1159/000356661
关键词: Mesenchymal stem cellsNa+/H+ exchanger 1 (NHE1)Intracellular pH (pHi)Osteogenic differentiationAdipogenic differentiationΒ-catenin
原始语种摘要: Background/Aims: Na+/H+ exchanger 1 (NHE1) is an important regulator of intracellular pH (pHi). High pHi is required for cell proliferation and differentiation. Our previous study has proven that the pHi of mesenchymal stem cells is higher than that of normal differentiated cells and similar to tumor cells. NHE1 is highly expressed in both mesenchymal stem cells and tumor cells. Targeted inhibition of NHE1 could induce differentiation of K562 leukemia cells. In the present paper we explored whether inhibition of NHE1 could induce differentiation of mesenchymal stem cells. Methods: MSCs were obtained from human umbilical cord and both the surface phenotype and functional characteristics were analyzed. Selective NHE1 inhibitor cariporide was used to treat human umbilical cord-derived...
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  • mesenchymal 间叶细胞的
  • osteogenic 成骨的
  • umbilical 供应脐带
  • cells 麻风细胞
  • adipogenic 生脂的
  • induce 诱导
  • treatment 处理
  • differentiated 区别
  • regulated 规定
  • regulator 第器