|作者：||Mesut Yıldız, Mehmet Vural, Mehmet Emin Erdal, Özlem İzci Ay, Şenay Görücü Yılmaz, İbrahim Fatih Karababa, Salih Selek|
1epartment of Psychiatry, Faculty of Medicine, Gaziosmanpaşa University, Tokat, Turkey.
2Department of Obstetrics and Gynecology, Faculty of Medicine, Harran University, Sanliurfa, Turkey.
3Department of Medical Biology and Genetics, Faculty of Medicine, Mersin University, Mersin, Turkey.
4Department of Psychi
|刊名：||Iranian Journal of Reproductive Medicine, 2015, Vol.13 (4), pp.221-226|
|来源数据库：||Directory of Open Access Journals|
|原始语种摘要：||Background: Premenstrual dysphoric disorder (PMDD) is a mood disorder characterized with physical and affective symptoms during the luteal phase of susceptible women. Objective: The aim of this study was to investigate the association of Dopamine D3 receptor (DRD3) polymorphism, and Cannabinoid receptor Type 1 (CNR1) polymorphism with PMDD. Materials and Methods: Fifty one participants with documented PMDD according to the DSM IV criteria and 51 healthy controls were included in this cross sectional study. Symptom severity was measured with daily self-rating, monthly premenstrual assessment forms and psychiatric interviews. The genotyping of DRD3 receptor and Cannabinoid type 1 receptors were performed using Taqmanfluorogenic assay method. Results: Distribution of DRD3 and CNR1... polymorphism was not different between patients and controls. Conclusion: These findings do not support a major role of DRD3, and CNR1 polymorphisms in contributing to susceptibility to premenstrual dysphoric disorder.|