Lack of association of DRD3 and CNR1 polymorphisms with premenstrual dysphoric disorders
作者: Mesut YıldızMehmet VuralMehmet Emin ErdalÖzlem İzci AyŞenay Görücü Yılmazİbrahim Fatih KarababaSalih Selek
作者单位: 1epartment of Psychiatry, Faculty of Medicine, Gaziosmanpaşa University, Tokat, Turkey.
2Department of Obstetrics and Gynecology, Faculty of Medicine, Harran University, Sanliurfa, Turkey.
3Department of Medical Biology and Genetics, Faculty of Medicine, Mersin University, Mersin, Turkey.
4Department of Psychi
刊名: Iranian Journal of Reproductive Medicine, 2015, Vol.13 (4), pp.221-226
来源数据库: Directory of Open Access Journals
原始语种摘要: Background: Premenstrual dysphoric disorder (PMDD) is a mood disorder characterized with physical and affective symptoms during the luteal phase of susceptible women. Objective: The aim of this study was to investigate the association of Dopamine D3 receptor (DRD3) polymorphism, and Cannabinoid receptor Type 1 (CNR1) polymorphism with PMDD. Materials and Methods: Fifty one participants with documented PMDD according to the DSM IV criteria and 51 healthy controls were included in this cross sectional study. Symptom severity was measured with daily self-rating, monthly premenstrual assessment forms and psychiatric interviews. The genotyping of DRD3 receptor and Cannabinoid type 1 receptors were performed using Taqmanfluorogenic assay method. Results: Distribution of DRD3 and CNR1...
全文获取路径: DOAJ  (合作)

  • dysphoric 烦燥不安的
  • premenstrual 经前的
  • CNR Composite Noise Rating
  • disorder 无序
  • receptor 接受体
  • polymorphism 多晶形
  • controls 控制机构
  • findings 结论
  • association 联合
  • assessment 评价